Question special

Based on the supplemental material in the ADRENAL trial (S4B), we see a significant difference/improvement in hemodynamic parameters (increased MAP and decreased HR) during the seven days that hydrocortisone was administered, which quickly dissipated after cessation of steroids. Perhaps this is the reason steroids have been previously shown/and confirmed to have a faster shock reversal effect. And of course one of the reassuring findings in both studies was a lack of increased clinically significant adverse effects aside from hyperglycemia. Given this, do you think it is plausible we may see an even greater benefit with longer duration of therapy?