Thanks for your thoughtful answers and comments. Also with respect to subpopulations, 24% of the patients included in the study never received an ACS diagnosis. This is really important as it's directly applicable to care in the emergency setting, where patients are often initially diagnostically undifferentiated.
For certain non-cardiac diagnoses we tolerate a lower oxygen saturation in the emergency setting (e.g. SpO2 above 88% for patients with COPD exacerbations, nominally to prevent hypercarbia from respiratory suppression). Additionally, the present trial uses an O2 saturation of 90% as the cut off for hypoxia, where other centers might use 92-93%. Is it possible that for cardiac diagnoses as well, a lower oxygen saturation could be tolerated (or even beneficial)? Are there any subpopulations in the registry that might be investigated to this end?
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