Cantos is a secondary prevention trial,canakinumab were used together with other drugs,including aspirin and statins,drugs with anti-inflammatory ability,not all pts of trial population have the same response to these drugs,so decreased level of CRP may took place because of anti-inflammatory activity of aspirin and statins as well as canakinumab.Therefore,why did not trialists use the same population as in JUPITER ? In that case,if we have Jupiter population,primary prevention,so trialists could use canakinumab without aspirin and statins, we could see relatively pure effect of canakinumab on inflamation,LDL and endpoints.
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