To follow up on Dr. Sullivan’s comments on the use of test negative design (TND), most studies using TND occur in outpatient settings presumably to account for confounding. Was this a reason for excluding patients from the inpatient setting with acute respiratory illness (who met study criteria) during influenza season?
If feasible in future VE studies, is there a role for including patients in other healthcare settings (i.e. inpatient or long term facilities) while accounting for possibly higher vaccine uptake and higher severity of illnesses among these individuals?
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