Thank you experts for the great discussion so far! The discussion brought to mind this observation (correct me if I'm wrong!): the drugs that have show good CV benefits are also the ones that are associated with weight loss, e.g. SGLT2 inhibitors and GLP-1 agonist (and the curious reason why the DPP-4 inhibitors don't seem to have as much CV benefit despite being in a common pathway). How much of the benefit from these drugs can be explained by weight loss alone (i.e. if someone can lose that much weight with lifestyle changes, how much do they gain comparatively)?
As a secondary question, we are taught to think of type 2 diabetes as a disease of glucose control dysregulation. Do you foresee a future shift in the paradigm and our approach to its management? For example, hyperglycemia may just be a manifestation of a broader metabolic derangement and how the body interacts with nutrient intake and energy expenditure. Perhaps longterm follow up data from the bariatrics surgery literature will point to a future where aggressive weight loss becomes first line focus for diabetes (meaning, we prescribe weight loss medications whose principle mechanisms are not to reduce blood glucose level)?
Easy one-click social registrationIs this safe?
We only receive the minimum information necessary to verify your account. We never get access to your friends/contacts or your profile, and we never post on your behalf. Your social account is used for logging in only.ORRegister via email
Send me updates on this Contest
In order to ensure a fair voting process and to make sure that no one votes more than once, we ask that you register either with a social networking account (easiest, only requires one click) or by registering with your email address (this will require you to click on a verification email that we will send you).
You only need to register once.