Question special
Lead Moderator

The 2016 Surviving Sepsis Guidelines provide a strong recommendation with low quality of evidence that the initial management of sepsis-induced hypoperfusion include at least 30ml/kg of intravenous crystalloid fluid within the first 3 hours.

In this study, however, time to completion of the fluid bolus appeared to have no effect on in-hospital mortality.

What should clinicians take away from the results of this study with regards to the initial fluid bolus--Is it not necessary? Helpful to some but harmful to others? Not interpretable due to confounding by indication?