Question normal

A few questions regarding organisms isolated:

1) Can you elaborate on the the data hinting that isolation of a gram positive organism is relatively protective (compared to culture negative and isolation of Gm-neg or other)?

Were coagulase-negative staphylococci and other likely contaminants included in the gram positive group? If removed does the gram positive effect move even further toward in hospital death being less likely?

2) Supplementary data report 'other' positive blood culture as including anaerobes, yeasts/moulds and viruses - was subgroup analysis possible here? And I'm curious about positive blood culture for virus, is this truly culture or viraemia detected via molecular methods?

3) Was it possible to assess the likelihood that first-line antibiotics were appropriate even at hospital level considering local resistance patterns?