Question special
Faculty Member

Question for authors/faculty: Do you think it makes a difference on what dose of aspirin is used. In this study a dose of 100mg was used but in practice 81mg is used and I wonder if a higher dose such as 325mg would have made any difference. The challenge is to what degree of anticoagulant effect are we trying to achieve to get this longer term benefit and how do we monitor that. With warfarin we can target specific goals of INR but with aspirin and Factor Xai we often make assumptions (as of now at least).

Data for aspirin in AF for stroke prevention yield very different results as far as benefit so I wonder if it is similar for VTE. I have always pondered this question but would love to hear the authors' thoughts on this.