The per-year relative risk reductions in the CTT meta-analyses have often been interpreted as being stable by 2 years, and RRR persists through the rest of the follow-up period: a 23% RRR/1 mmol/L at year 2 in CTT (or a 37% RRR/1.6 mmol/L reduction LDL-C). In contrast, the FOURIER 2.3 year RRR for CTT endpoint was 17%/1.6 mmol/L LDL-C reduction (FOURIER Table 2). Can you walk the audience through your analysis?
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