Question special
Lead Moderator

The recent EAS statement on LDL causality for CVD (Ference B, et al, Eur Heart J 2017) reported a log linear association between LDL-C level and CVD in randomized trials with follow-up of about 5 years, prospective cohort studies with about 10-year follow-up, and Mendelian randomization studies over a lifetime of exposure. That is, the relative risk reduction might be less when LDL-C levels are lower. Do you think the relative reductions in CVD risk in FOURIER reflects this and why?