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Welcome! In December, the editors of NEJM Journal Watch General Medicine chose the most important and clinically relevant research topics from 2016. In this discussion and another that will start in a few weeks, we’d like to discuss how some of 2016’s top research papers will affect clinical practice. So, first, I’d like to ask NEJM JW General Medicine editors – Dr. Brett and Dr. Mueller – to explain why they chose these papers on cardiovascular outcomes as some of the best of 2016. All are welcome to freely ask, answer, respond, and follow-up with posts.