Congratulations again to the authors for a very impactful study. To start, I want give the authors and experts a chance to speak generally about the significance of this study. What are the greatest clinical implications based on the findings that showed antenatal antiretroviral therapy (ART) to significantly lower early HIV transmission versus zidovudine/single-dose nevirapine (ZDV/sdNVP) alone, but also higher adverse maternal/neonatal outcomes. How should care be directed to balance the superior efficacy but increased safety concerns of ART?
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