Question special

11% of the patients in the study had an active cancer – PE as a highly likely cause for SOB, syncope, hypoxia, in this population. In your view, how reliable are D-dimer and the Wells score in addressing pre-test probability in cancer patients? By using these parameters, is the population enriched for those with malignancy (high d-dimer and clinical pre test probability)? How do you believe this study affects patients with active malignancy?