Why is now the right time to update the way we define sepsis? Has our understanding of sepsis fundamentally changed over the past decade based on new research/discovery thereby necessitating new definitions? Or, as Dr. JL Vincent suggests, has sepsis always been "a substantial and deleterious response to an infection ( 10.1186/s13054-016-1389-z)" and Sepsis III represents a return to that concept?
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