Question special
Lead Moderator

Why is now the right time to update the way we define sepsis? Has our understanding of sepsis fundamentally changed over the past decade based on new research/discovery thereby necessitating new definitions? Or, as Dr. JL Vincent suggests, has sepsis always been "a substantial and deleterious response to an infection ( 10.1186/s13054-016-1389-z)" and Sepsis III represents a return to that concept?