Hello everybody, and welcome to this NEJM Open Group Forum discussion on the article, “Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer.” My name is Nicholas and I will serve as a moderator for this thread for the duration of the discussion period. First off, I would like to congratulate Dr. Pritchard and colleagues on their novel study which characterized for the first time the frequency of inherited DNA-repair gene mutations in patients with metastatic prostate cancer and which identified mutations in 16 different DNA-repair genes associated with autosomal dominant syndromes predisposing for cancer. In addition, I would like to thank the experts who have generously given their time to provide insights as we delve more deeply into this important topic. As an introduction, this open forum is meant to encourage discussion and questions from individuals with differing levels of knowledge; I welcome all our guests to ask questions and encourage all our authors and experts to answer any questions that are posed. I hope this forum will exciting place for interactive discussion over the next 10 days. Welcome!
Easy one-click social registrationIs this safe?
We only receive the minimum information necessary to verify your account. We never get access to your friends/contacts or your profile, and we never post on your behalf. Your social account is used for logging in only.ORRegister via email
Send me updates on this Contest
In order to ensure a fair voting process and to make sure that no one votes more than once, we ask that you register either with a social networking account (easiest, only requires one click) or by registering with your email address (this will require you to click on a verification email that we will send you).
You only need to register once.