Question special
Lead Moderator

Happy Saturday to all - today's question focuses on potential follow-up studies to the LEAP + LEAP-ON efforts.

From the manuscript, "Overall through introduction in the first year of life, peanut consumption for the following 4 years and a year of peanut abstinence there was a 74% relative reduction in the prevalence of peanut allergy in the LEAP consumers compared to LEAP avoiders, demonstrating longer-lasting unresponsiveness to peanut following 12 months of peanut avoidance."

As alluded to by several experts including the authors - might it be important to do a 2, 5, and/or 10-year follow-up? Why or why not?

Importantly - if ultimately peanut allergies can be solely ‘delayed’ (there was some conversion to allergic status at 72 months - potentially more conversion by e.g. 96 months, etc.), and not completely prevented via early exposure, then is there truly a benefit to early exposure?