Question normal

Thank you for such an important paper. Not only is it clinically important, but it provides an outstanding example of thoughtful research design (accounting for multiple kidneys, etc.) and the ethical challenges surrounding studies of organ donation.

On the note of methods, could you discuss the choice of ECD versus KDPI? Were there further exploratory analyses to see if there was indeed a threshold effect (around KDPI 85), or perhaps it had a different shape to the relationship?

Considering the subgroup analysis results, why do you think the SCD vs. ECD effect estimate is not significant in the primary analysis? Is it because the ECD definition also considers age and creatinine?

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