Question special

The rate of the primary outcome was lower than expected, as mentioned in the paper. The trends for the composite primary outcome and the individual components (except for nonfatal MI) are in the direction of possible benefit in the CT strategy. Our patients in Queens, NY, a very ethnically diverse community, are likely to have higher rates of comorbidities and risk factors, and I suspect that the rates of the primary outcome would be higher. Can you speculate about whether you think the results might be different in a higher risk population?