Question special
Faculty

If the calorie consumption was significantly higher before trial enrollment, are we concerned that on trial completion, participants could return to baseline calorie consumption, or at least close? I am thinking about extrapolating the results to our real world, clinical setting. If my patient is consuming 2300 calories and I tell her to reduce her intake to 1500 but maintain the same level of physical activity (or more because many people who start a 'diet' also start exercising at the same time), chances are she will feel deprived and cranky and resort to what she was doing pre-trial, soon after the study ends.