I was curious as to others thoughts about the data that shows a significant increased in the >30% drop in GFR in the intensive control group. In the discussion there is a note that these events were one time, mild, and recovered fully so would be more consistent with an episode of AKI rather then true decreased renal function throughout the course of the study. Looking at the supplementary index there was no difference in the use of ACE/ARB but there is a difference in use of diuretics both thiazide and aldosterone blocking agents.
With the known benefit in heart failure patients from Aldosterone blocking diuretics could this be a confounder of the improvement data seen?
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