1) I think the antibiotic regimen for those in the antibiotic only arm was not specified for the partner sites in the protocol, is that correct? Was this perhaps because it is difficult to standardize an antibiotic regimen across many sites? And, maybe similarly, it's hard to require sites to hospitalize these patients for a set period of time. I wonder if antibiotic only arm patients were required to be hospitalized for 24 hours, if that would have changed their need for appy or having complications, maybe if their clinical course was observed? But then again, it seemed that the LOS between the arms wasn't terribly different.
2) Treatment response to antibx at 10 days was clinically defined as resolution of symptoms (fever, abd pain, tenderness to palpation), correct? 11% of that group required 2nd course of antibx. Was it built into the protocol to always do trial of 2nd course of antibx, instead of crossover into appy directly? Or were there certain criteria that would warrant crossover after 1st antibx treatment failure.
As internists that would help take care of these patients potentially, we think about antibx stewardship and untoward effects of multiple courses of antibiotics, and so I wonder how this subset of antibx only arm that had 2 courses of antibx did with regards to outcomes, complications, and adverse effects. Thank you!
Easy one-click social registrationIs this safe?
We only receive the minimum information necessary to verify your account. We never get access to your friends/contacts or your profile, and we never post on your behalf. Your social account is used for logging in only.ORRegister via email
Send me updates on this Contest
In order to ensure a fair voting process and to make sure that no one votes more than once, we ask that you register either with a social networking account (easiest, only requires one click) or by registering with your email address (this will require you to click on a verification email that we will send you).
You only need to register once.