The role of Renin–Angiotensin–Aldosterone System in the immune system 's function has been under exploration "somewhat reservedly and disappointingly slowly".
At least, within the gut-brain circuit the Renin–Angiotensin–Aldosterone System has a weight.
From the genomic point of view, Renin–Angiotensin–Aldosterone System has a role in gut-brain axis, that is yet to be thoroughly investigated.
Technological progress in metagenomic and metabolomic analyses have led to the understanding that disruption of the normal gut microbiota may lead to intestinal dysbiosis, intestinal barrier dysfunction, and bacterial translocation. Hence, one can think of the opposite scenario!
Furthermore, dysbiosis and bacterial translocation enhance uremic toxins production that includes: indoxyl sulphate, p-cresyl sulphate, and trimethylamine-N-oxide. All the above have been implicated in the variant processes of kidney diseases development therefore an impact on the Renin-Angiotensin-Aldosterone trilogy.
Thus there is an association between 1) gut microbiota [i.e.T-Cells, CAR-T , etc./immune system health] which is regulated by brain and in turn, it regulates brain function [i.e. neurotransmitters], and 2) kidney/surenal gland function or the gut-kidney axis.
In other word, Renin-Angiotensin-Aldosterone system (and inhibitors), CKD, IgM, IgA nephro-pathies/lithiasis, and hypertension are closely associated with dysbiosis: Brain-Gut-Kidney trilogy!
Perhaps a quadrology?
Brain-Gut-Immune system (including Covid-19, Infectious dis., Cancer, Neurodegen. & Cardiovas.dis)-Kidney!
Easy one-click social registrationIs this safe?
We only receive the minimum information necessary to verify your account. We never get access to your friends/contacts or your profile, and we never post on your behalf. Your social account is used for logging in only.ORRegister via email
Send me updates on this Contest
In order to ensure a fair voting process and to make sure that no one votes more than once, we ask that you register either with a social networking account (easiest, only requires one click) or by registering with your email address (this will require you to click on a verification email that we will send you).
You only need to register once.