Question normal

The role of Renin–Angiotensin–Aldosterone System in the immune system 's function has been under exploration "somewhat reservedly and disappointingly slowly".
At least, within the gut-brain circuit the Renin–Angiotensin–Aldosterone System has a weight.
From the genomic point of view, Renin–Angiotensin–Aldosterone System has a role in gut-brain axis, that is yet to be thoroughly investigated.
Technological progress in metagenomic and metabolomic analyses have led to the understanding that disruption of the normal gut microbiota may lead to intestinal dysbiosis, intestinal barrier dysfunction, and bacterial translocation. Hence, one can think of the opposite scenario!
Furthermore, dysbiosis and bacterial translocation enhance uremic toxins production that includes: indoxyl sulphate, p-cresyl sulphate, and trimethylamine-N-oxide. All the above have been implicated in the variant processes of kidney diseases development therefore an impact on the Renin-Angiotensin-Aldosterone trilogy.
Thus there is an association between 1) gut microbiota [i.e.T-Cells, CAR-T , etc./immune system health] which is regulated by brain and in turn, it regulates brain function [i.e. neurotransmitters], and 2) kidney/surenal gland function or the gut-kidney axis.
In other word, Renin-Angiotensin-Aldosterone system (and inhibitors), CKD, IgM, IgA nephro-pathies/lithiasis, and hypertension are closely associated with dysbiosis: Brain-Gut-Kidney trilogy!
Perhaps a quadrology?
Brain-Gut-Immune system (including Covid-19, Infectious dis., Cancer, Neurodegen. & Cardiovas.dis)-Kidney!