Since the onset of the pandemic, I like many internal medicine residents have had the opportunity to care for COVID-19 patients in the ward, ICU, and telehealth arenas. With I'm sure the best of intentions, there have been numerous clinical fads with little or no supporting data regarding what we should do (e.g. hydroxychloroquine, azithromycin, etc.) and what we should not do (e.g. ACEI/ARBs, NSAIDs, steroids, etc.). We've already backtracked in a big way on many of them. It's been fascinating but also alarming, and hits close to home when you are in the thick of the action trying to make good decisions for patients. Having been through the process of testing a clinical hypothesis and getting a result that refutes an early assumption in a novel disease, how has your viewpoint changed with regard to rapid adoption of indeterminately helpful vs harmful treatment strategies prior to supportive research in the future?
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