Question special

How did the requirement for patients/caregivers to agree prospectively to pay for alteplase affect recruitment? How many patients were evaluated for inclusion but did not participate solely due to the alteplase payment requirement (Figure 1 not entirely clear from this standpoint)? Were any patterns noted with patients that could not pay or did not agree to pay? Did any of the 41 included trial centers suffer from high rates of inability for patients to pay for alteplase? Thank you in advance