A number of experts have commented that since the Rivers trial in 2001, the “usual care” of sepsis has improved, as we have become better at early recognition and treatment with IV fluids, antibiotics, vasopressors, etc. Thus, sepsis-related mortality rates have generally decreased. Is there potential to further drive down complication and mortality rates, or is this the best that can be expected without novel therapies being attempted? If improvements can be made, how much is realistic?
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