Question special

Dr. Barrot, Thank you for your excellent explanation you provided to Dr. Jackson's question on proning as it related to outcomes. I am interested to know if there was any signal in your data to suggest whether early proning vs late proning was more beneficial? The PROSEVA Trial only studied proning in severe ARDS (based on P:F ratio) initiated in the early mechanical ventilation period (within 36 hours). I not familiar with any studies that have looked at the effects of proning as salvage therapy later in the course.