In your methods section under ventilation and weaning protocol, volume assist-control was recommended and it would seem that this recommendation was not strictly followed, as in the results there were more patients breathing volume assist-control mode in the liberal oxygen group compared to the conservative oxygen group not to mention a slightly lower PEEP in the conservative group. Was there a greater amount of patients on pressure control ventilation in the conservative oxygen group?
I think this is worth reviewing if possible because pressure control ventilation does have its advantages in patients with ARDS who tend to have significantly reduced lung compliance, possibly recreuit additional lung units more effectively, improves synchrony, and results in a lower peak airway pressure for the same tidal volume that a volume assist ventilation would provide. If there is indeed a greater amount of pressure control ventilation in the conservative group, could this possibly be a clinician bias as I understand that this is an open label study.
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