Another point of interest for me was that, among the 62 patients randomized to surgery and who underwent at least 6 months of follow-up, 20 ultimately underwent surgery, resulting in an overall crossover rate of 32%.
How does that finding influence how you would recommend incorporating the results of this trial into clinical counseling, from a practical perspective?
Informally, based on the trial, would you advise patients that a one-in-three chance of ultimately undergoing surgery anyway is sufficient to justify avoiding the additional time spent with worse leg pain, potentially not able to work, etc.--particularly when combined with the significantly increased pain scores at 6-months and 12-months among those who underwent non-operative management, as compared to those who underwent diskectomy?
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