One of the components of the initiative is the assembly of a longitudinal cohort of 1 million individuals, with extensive genetic data and health information. Is a cohort of 1 million people enough? What lessons have we learned from existing cohorts (e.g., Framingham Heart Study) and how do we leverage these cohorts? How will the assembly of this cohort interact with other efforts such as the Global Alliance for Genomics and Health? Should this be a federated model, where many institutions collect smaller cohorts that are then connected by the NIH? Or should it follow a centralized model? What kinds of information will we need to collect? How do we encourage individuals to participate and maximize the utility of their information, while ensuring their privacy?
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