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Hello everyone,
Thank you for hosting this discussion and thanks for the authors
It’s a great article and results are promising
I think COPD patients presenting with worsening symptoms and low CRP can also alarm us to other possible non-infectious etiologies like PE
I have a question though regarding the study design
When were the patients allocated to CRP guided group or usual-care group? Is it before baseline Data and sputum cultures, or people were given early follow up appointments to allocate them?
Another question, since CRP rise can lag behind, would following a trend of rise in CRP be more specific to infectious etiology rather than one time POCT testing, esp. that we see a lot of COPD patients with multiple comorbidities having CRP higher than 40 even with minimal symptoms
Thank you