As noted in the paper, the treatment group had significantly better outcomes compared to the control group for individuals aged 4 to 17, while there was no difference between the groups for individuals 18 years of age or older. Was there a reason that 17 years of age was used as the cut-off for the analysis? It appears that the treatment outcomes are age-dependent. Based on results that the between-group difference for the 600-mg challenge was slightly higher for children than adolescents, would you hypothesize that there is an age during childhood in which it is optimal to provide this treatment?
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