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David and Donald, thanks so much for the great interactions and discussion so far. This is a question that is more broadly focused. Given your expertise and experience in conducting large clinical trials in ED and critical care settings, I wondered if you would comment on the following: What regulatory changes or clinical trial design innovations (e.g. adaptive randomization design, etc.) are you most interested in or do you think would be most useful to improve the efficiency, speed and cost-effectiveness of conducting important trials like the ProACT study without compromising the quality and rigor of the study results that are generated? We all can see that funding for all types of medical research is becoming harder to secure so we must stretch to get the most out of what is available. Thanks for any thoughts or insights.