Question special

I’m excited for this discussion! Thanks to everyone who has made this possible!

I see that Figure S2 evaluates clinician adherence based on procalcitonin tier and day. When the authors report that guideline adherence was approximately 60-65% throughout the trial, does one nonadherent antibiotic dose when procalcitonin levels are <0.25 make the entire encounter nonadherent? Similarly does a missed dose of antibiotics when procalcitonin >0.5 count also count as nonadherence? Lastly, did patients with initial pro-calcitonin levels >0.5 have their subsequent labs drop below <0.25 throughout the hospital stay? If so, how did the authors address this?