What's New

The Pediatric Infectious Diseases rotation guide has been updated with the addition of recent research, reviews, and guidelines.

In this episode of Curbside Consults, we discuss the diagnosis and management of primary, secondary, and tertiary hyperparathyroidism with Dr. O.P. Hamnvik, who is an endocrinologist and educator at the Brigham and Women’s Hospital in Boston and the NEJM Group...

Defective synthesis of the β-globin chain causes recessively inherited disorders characterized by inadequate hemoglobin production and chronic anemia. Transfusion may lead to iron overload. Hematopoietic stem-cell transplantation may be curative. Gene...

The muscarinic receptor agonist xanomeline has antipsychotic properties without dopamine blockade. Cholinergic adverse events limit its use. When xanomeline was combined with trospium to limit peripheral effects, scores were better on measures of schizophrenia...

This review highlights the most important medical topics of 2020, as chosen by the editors of NEJM Journal Watch General Medicine.

In a 12-week, two-stage, double-blind, placebo-controlled trial published in NEJM, individuals with moderate-to-severe methamphetamine use disorder (MUD) were randomized to receive either a combination of extended-release injectable naltrexone...

Ms. Alvarez is a 68-year-old woman with hypertension, type 2 diabetes, and obesity. She presents to clinic with symptoms of cough, shortness of breath, and fever to 100.4°F for the last 2 days. She was recently exposed to a family member who tested positive for...