What's New

The IM Hematology rotation guide update includes ISTH guidelines for the diagnosis and treatment of thrombotic thrombocytopenia purpura and updated treatment algorithms for newly diagnosed myeloma and β-thalassemia.

Fifteen years after its publication, this 2006 landmark article continues to bestow knowledge and guidance to both teachers and learners of clinical reasoning. Read the annotated PDF and join the discussion on February 28th.

A 66-year-old woman with metastatic HER2-positive breast cancer returns to her oncologist after treatment with trastuzumab and pertuzumab, the standard first-line treatment, only to learn that her disease has progressed. The oncologist offers her two choices for second-line treatment: trastuzumab deruxtecan (T-DXd), a HER2 antibody...

A 29-year-old woman was evaluated for a soft-tissue mass in the pancreatic head, discovered after diarrhea and jaundice occurred. Diagnostic procedures were performed, and management decisions were made.

Until recently, Ph-positive ALL was very aggressive and difficult to treat. Current frontline therapy, based on tyrosine kinase inhibitors, glucocorticoids, and blinatumomab, has increased survival, with high-level clearance of measurable tumor cells.