• Critical Care Medicine
    • Associate Professor of Medicine at Vanderbilt University Medical Center

    Dr. Todd W Rice is a tenured associate professor of medicine in the Division of Allergy, Pulmonary and Critical Care Medicine at Vanderbilt University Medical Center.  Dr. Rice’s clinical and research interests are improving the care of critically ill patients, especially those with sepsis, ARDS, and acute respiratory failure.  He has authored more than 110 peer-reviewed publications and book chapters and has given more than 150 national and international lectures concerning advancing the care of critically ill patients.  He is a founding member of the Pragmatic Critical Care Trials Research Group and since 2011 has spent considerable research time conducting large, pragmatic trials of comparative effectiveness research in critically ill patients as part of the Vanderbilt Learning Healthcare System.  He has been federally funded since 2005.  Currently, he is the co-director of the Learning Healthcare Systems Platform in Vanderbilt’s Clinical and Translational Science Award (CTSA) and he also serves as the critical care PI for Vanderbilt’s NHLBI funded Prevention and Early Treatment of Acute Lung injury (PETAL) clinical center.  From 2005 through 2012, he served as an investigator in the NHLBI funded ARDS Network, where he designed and led three landmark trials.  Two of the trials investigated nutrition aspects of caring for critically ill patients (EDEN and OMEGA) and the third investigated critically ill patients with H1N1 influenza.  Dr. Rice has served as a consultant for the NIH, both on study sections and data and safety monitoring boards.  He also has served in leadership positions in numerous committees for the American Thoracic Society, American Society of Parenteral and Enteral Nutrition, Society of Critical Care Medicine, and American College of Chest Physicians.  

    • Emergency Medicine
    • Emergency Medicine Physician & Clinical Researcher at Vanderbilt University Medical Center

    Dr. Wesley H. Self, MD, MPH, is an Associate Professor of Emergency Medicine at Vanderbilt University Medical Center.  He is an emergency physician and clinical and translational researcher focused on T2 (translation to patients) and T3 (translation into practice) research in the fields of pneumonia, sepsis, and resuscitation. He was the principal investigator for the Saline Against Lactated Ringer’s or Plasmalyte in the Emergency Department (SALT-ED) trial. Dr. Self serves as the Director of the Emergency Critical Care Research Program at Vanderbilt and the co-principal investigator of the Vanderbilt Clinical Center in the NHBLI-funded Prevention and Early Treatment of Acute Lung Injury (PETAL) Clinical Trials Network (  He has authored over 100 peer-reviewed publications, mostly on the early management of pneumonia, sepsis, and related emergencies. Prior work has included detailed analyses of the epidemiology of community-acquired pneumonia (N Engl J Med 373:415; N Engl J Med 372:835).  Current work focuses on embedding pragmatic comparative effectiveness trials into ongoing clinical care to learn how to improve early resuscitation. 

    • Critical Care Medicine
    • Internal Medicine
    • critical care medicine
    • Assistant Professor of Medicine at Vanderbilt University Medical Center

    Dr. Matthew W. Semler is an assistant professor of medicine in the division of pulmonary and critical care medicine at Vanderbilt University Medical Center.  Dr. Semler’s research focuses on sepsis, acute respiratory distress syndrome (ARDS), and the conduct of comparative effectiveness trials within the delivery of clinical care.  After obtaining his M.D. at the University of Virginia, Dr. Semler completed a residency and chief residency in Internal Medicine, a fellowship in Pulmonary and Critical Care Medicine, and a Masters of Science in Clinical Investigation, all at Vanderbilt University.  With the support of his mentors, Drs. Gordon R. Bernard and Todd W. Rice, Dr. Semler has completed a series of randomized comparative effectiveness trial in the intensive care unit, focused primarily on fluid management and respiratory support.  He is currently supported by the Vanderbilt Emergency Care K12 to lead a cluster-randomized, cluster-crossover trial comparing 0.9% saline to balanced crystalloids among critically ill adults.  Dr. Semler is also a member of the PETAL Network, an NIH/NHLBI-sponsored network investigating novel therapies in the prevention and early treatment of acute respiratory distress syndrome.

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