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NEJM Journal Watch 2016 Year in Review – Opioid Overprescribing

Each year, the editors of NEJM Journal Watch General Medicine choose the most important thematic areas in clinical research for the year. We try to strike a balance among relevance to primary care, recognition of landmark studies, and acknowledgment of media publicity and public awareness. Topics can emerge from one important study or from several studies during the year. In 2016, important research on opioid prescribing patterns was published. Let’s discuss the newest data on inappropriate opioid use and how to combat patients’ pain without contributing to this ongoing problem.



1.      Racial Differences Persist in End-of-Life Care

2.      New Sepsis-3 Definitions Await Confirmatory Data

3.      Zika Makes Headlines

4.      With Oxygen, Could Less Be More?

5.      Randomized Comparison of Surgery, Radiotherapy, and Surveillance for Prostate Cancer

6.      Cardiovascular Outcomes with Newer Antidiabetes Drugs

7.      Does CPAP Prevent Adverse CV Events in Patients with Obstructive Sleep Apnea?

8.      Pulmonary Embolism as a Cause of Syncope

9.      And Finally … Rounding Out General Medicine’s 2016 Year in Review

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