Request to Join
has invited you to join this group
has invited you to join this group
Medical Epidemiologist at Centers for Disease Control and Prevention
Sarah H. Sell and Cornelius Vanderbilt Chair in Pediatrics at Vanderbilt University
Professor of Pulmonary Medicine at Northwestern University
Emergency Medicine Physician & Clinical Researcher at Vanderbilt University Medical Center
George and Esther Gross Presidential Professor / Chief, Division of Pediatric Infectious Diseases at University of Utah
Assistant Professor of Pediatrics, Division of Hospital Medicine at Vanderbilt University School of Medicine
Pulmonary Section Chief, Director of Pulmonary and Critical Care Medicine Fellowship Program at Eastern Virginia Medical School
Associate Professor at University of Wisconsin Hospital and Clinics
Assistant Professor of Medicine at Texas A&M Health Science Center
Associate Professor at the Department of Medicine, Division of Pulmonary/Critical Care Medicine at University of Texas Health Science Center at San Antonio
Director, Pulmonary and Critical Care Fellowship Program at Harvard-Brigham and Women’s Hospital
Pulmonary and Critical Care Medicine Fellow at Eastern Virginia Medical School
Chief Resident at University of Wisconsin Internal Medicine
Medical Student at Oakland University William Beaumont School of Medicine
Fellow at Baylor Scott & White
Critical Care Medicine - Translational Science PhD Student - University of Texas Health Science Center at San Antonio
Pulmonary Critical Care Fellow
Community-acquired pneumonia is a leading infectious cause of hospitalization and death among U.S. adults. Incidence estimates of pneumonia confirmed radiographically and with the use of current laboratory diagnostic tests are needed.
We conducted active population-based surveillance for community-acquired pneu-monia requiring hospitalization among adults 18 years of age or older in five hospitals in Chicago and Nashville. Patients with recent hospitalization or severe immunosuppression were excluded. Blood, urine, and respiratory specimens were systematically collected for culture, serologic testing, antigen detection, and molecular diagnostic testing. Study radiologists independently reviewed chest radiographs. We calculated population-based incidence rates of community-acquired pneumonia requiring hospitalization according to age and pathogen.
From January 2010 through June 2012, we enrolled 2488 of 3634 eligible adults (68%). Among 2320 adults with radiographic evidence of pneumonia (93%), the median age of the patients was 57 years (interquartile range, 46 to 71); 498 patients (21%) required intensive care, and 52 (2%) died. Among 2259 patients who had radiographic evidence of pneumonia and specimens available for both bacterial and viral testing, a pathogen was detected in 853 (38%): one or more viruses in 530 (23%), bacteria in 247 (11%), bacterial and viral pathogens in 59 (3%), and a fungal or mycobacterial pathogen in 17 (1%). The most common pathogens were human rhinovirus (in 9% of patients), influenza virus (in 6%), and Streptococcus pneumoniae (in 5%). The annual incidence of pneumonia was 24.8 cases (95% confidence interval, 23.5 to 26.1) per 10,000 adults, with the highest rates among adults 65 to 79 years of age (63.0 cases per 10,000 adults) and those 80 years of age or older (164.3 cases per 10,000 adults). For each pathogen, the incidence increased with age.
The incidence of community-acquired pneumonia requiring hospitalization was highest among the oldest adults. Despite current diagnostic tests, no pathogen was detected in the majority of patients. Respiratory viruses were detected more frequently than bacteria. (Funded by the Influenza Division of the National Center for Immunizations and Respiratory Diseases.)
Medical Epidemiologist at Centers for Disease Control and Prevention
Sarah H. Sell and Cornelius Vanderbilt Chair in Pediatrics at Vanderbilt University
Professor of Pulmonary Medicine at Northwestern University
Emergency Medicine Physician & Clinical Researcher at Vanderbilt University Medical Center
George and Esther Gross Presidential Professor / Chief, Division of Pediatric Infectious Diseases at University of Utah
Assistant Professor of Pediatrics, Division of Hospital Medicine at Vanderbilt University School of Medicine
Pulmonary Section Chief, Director of Pulmonary and Critical Care Medicine Fellowship Program at Eastern Virginia Medical School
Associate Professor at University of Wisconsin Hospital and Clinics
Assistant Professor of Medicine at Texas A&M Health Science Center
Associate Professor at the Department of Medicine, Division of Pulmonary/Critical Care Medicine at University of Texas Health Science Center at San Antonio
Director, Pulmonary and Critical Care Fellowship Program at Harvard-Brigham and Women’s Hospital
Pulmonary and Critical Care Medicine Fellow at Eastern Virginia Medical School
Chief Resident at University of Wisconsin Internal Medicine
Medical Student at Oakland University William Beaumont School of Medicine
Fellow at Baylor Scott & White
Critical Care Medicine - Translational Science PhD Student - University of Texas Health Science Center at San Antonio
Pulmonary Critical Care Fellow