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Dr. Mofenson is an infectious disease specialist and board-certified pediatrician. She has spent her career doing research on the prevention and treatment of pediatric and maternal HIV infection in the US and globally. She has authored or coauthored more than 340 peer-reviewed publications and book chapters, primarily related to pediatric HIV infection. She joined the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health (NIH) in 1989, first as Associate Branch Chief for Clinical Research in the Pediatric, Adolescent and Maternal AIDS Branch, and then as Branch Chief in the Maternal and Pediatric Infectious Disease Branch. At the NIH, she was responsible for program planning and development and scientific direction of research studies and clinical trials in domestic and international pediatric, adolescent and maternal HIV/AIDS infection. In 2012, she received the Federal Employee of the Year Samuel J. Heyman Service to America Award for her work on prevention of mother-to-child HIV transmission. She is a member of the U.S. Public Health Service Guidelines Panels for treatment of HIV-infected children, treatment of HIV-infected pregnant women and prevention of mother to child HIV transmission, and prevention and treatment of opportunistic infections in children (serving as Executive Secretary for these guidelines through 2014), and continues to provide consultation to the World Health Organization on treatment guidelines in resource-limited countries. She retired from the NIH in September 2014 after 26 years of service, and currently serves as Senior HIV Technical Advisor for the Elizabeth Glaser Pediatric AIDS Foundation, where she is involved in implementation science research on pediatric and maternal HIV treatment in Africa.
As a pediatrician and clinical researcher I have devoted my research career over the past 26 years to prevention of mother to child transmission (PMTCT) and treatment and care of pediatric HIV infection with a focus on testing feasible PMTCT interventions which are cost effective and deliverable in resource limited settings among breastfeeding HIV Infected women. In my research work on PMTCT, I have been involved with studies looking at transmission of resistant virus in PMTCT studies and its potential impact and risk of later treatment failure. I currently serve as Chair of the PROMISE 1077BF protocol. In that capacity I would look forward to working closely with the other co-investigators in PROMISE to publish the important safety and efficacy information from this large multi-site international PMTCT trial.
Dr. David E. Shapiro is a Principal Research Scientist in the Center for Biostatistics in AIDS Research at the Harvard T. H. Chan School of Public Health. Dr. Shapiro has worked as a senior statistician for perinatal and pediatric HIV research studies for 22 years, as a member of the NIH-funded Statistical and Data Management Center (SDMC) for the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network and its predecessor the Pediatric AIDS Clinical Trials Group (PACTG). He served as the SDMC’s Perinatal Section Head from 1995 through 2006, its Associate Director from 2003 through 2010, and has been the SDMC Director since 2010. Dr. Shapiro has taken the lead statistical role in 24 perinatal and pediatric HIV clinical trials, including Phase I, II, and III trials and observational studies in the U.S. and internationally, and has served as a member or chair of the independent data and safety monitoring committee for three clinical trials. He has authored or co-authored 60 peer-reviewed publications. Dr. Shapiro’s statistical research interests and publications focus on methodology for assessing the accuracy of diagnostic and screening tests.
Pediatric Pat Flynn, M.D., is a Member in the Department of Infectious Diseases at SJCRH where she holds the Arthur Ashe Chair in Pediatric AIDS Research. She is also Professor of Pediatrics and Preventive Medicine at the University of Tennessee Health Science Center. She received her medical training at Louisiana State University Medical Center (1981) and completed Pediatric (1984) and Pediatric Infectious Diseases (1987) training at the University of Tennessee/St. Jude Children’s Research Hospital/LeBonheur Children’s Medical Center joint program. Dr. Flynn began working in the HIV/AIDS program at St. Jude Children’s Research Hospital in 1988. Over the past 28 years, she has had the opportunity to watch the dramatic reductions in the rate of mother to child HIV transmission and the introduction of active medications that extend the life of HIV-infected persons. She has also witnessed the rising new infection rates in the adolescents through high risk behaviors. The St. Jude HIV clinic provides comprehensive care for over 300 HIV- infected infants, children, and adolescents. Dr. Flynn and the St. Jude clinic participate in the International Maternal Pediatric and Adolescent Clinical Trials Group (IMPAACT) and the Pediatric HIV/AIDS Cohort Study (PHACS).