About the Discussion

@NEJM Ask the Authors & Experts: Benefits and Risks of Antiretroviral Therapy for Perinatal HIV Prevention

Randomized trial data are lacking on risk/benefits of antiretroviral therapy (ART) versus zidovudine/single-dose nevirapine (ZDV/sdNVP) to prevent HIV transmission in HIV-infected pregnant women with higher CD4 counts. This landmark clinical trial found that antenatal ART resulted in significantly lower early HIV transmission than ZDV- alone, but higher risk of adverse maternal/neonatal outcomes.