• Family Medicine
    Patricia Franklin, MD MBA MPH is Professor and Executive Director of Research, Musculoskeletal Center of Excellence, University of Massachusetts Medical School. Following a residency in Preventive Medicine, she completed a fellowship in Health Services Research emphasizing large database design and analysis and inter-disciplinary chronic care models. This training laid the foundation for a career in quality improvement (as Medical Director for Quality) and in outcomes research. With funding from NIH, AHRQ, RWJF, FDA, and PCORI, Dr. Franklin's research aspires to improve measurement strategies to support optimal physical function, especially among patients with knee and hip osteoarthritis. She currently serves as Principal Investigator on a program project award (AHRQ; FORCE-TJR) to conduct comparative effectiveness research in total joint replacement (TJR). This national effort enrolled more than 25,000 TJR patients from over 200 orthopedists in 28 states to determine best practices to achieve optimal pain relief and physical function for adults with knee and hip arthritis. Based on the FORCE-TJR experience collecting patient-reported outcomes, she and her colleagues developed a framework for implementing PROs broadly in clinical care (funded by AHRQ/Academy Health). In addition, Dr. Franklin recently completed a randomized trial (NIAMS; RO1) to evaluate the longitudinal impact of a telephone-based arthritis self-management program to enhance physical activity for advanced arthritis patients who elect surgical care. Dr. Franklin also served as informatics co-investigator on the UMMS Clinical and Translational Science Award and PI of a CTSA-funded pilot study using accelerometry in arthritis patients to quantify and improve physical activity.
    • Family Medicine
    • Internal Medicine
    An internist and clinical epidemiologist, over the past 25 years I have had leading roles in the conceptualization, conduct, and interpretation of numerous clinical trials and epidemiological studies. Many of these have addressed important issues in the epidemiology and prevention of cancer and other chronic diseases. As a member of the Steering Committee of the Colon Cancer Family Registry, I have helped develop one of the largest cohorts of colorectal cancer cases in the world, an important resource for the study of the genetics of colorectal cancer. I am active in the Early Detection Research Network, where I serve as the clinical epidemiologist for a validation center investigating gastrointestinal early detection markers. I lead the Polyp Prevention Study Group (PPSG), which has conducted several important adenoma prevention clinical trials that have been instrumental in clarifying the effects of antioxidants, calcium, aspirin, and folic acid on the risk of colorectal neoplasia. These studies have also been vehicles for the investigation of the association of colorectal neoplasia (including serrated polyps) with a wide range of genetic, life style and metabolic factors. I have served on the Safety and Data Monitoring Boards of several prominent trials, including SELECT and the DFMO/sulindac trial reported by Meyskens et al. I have broad experience mentoring junior investigators, several of whom have become prominent investigators.
    • Orthopaedic Surgery
    • Sports injuries
    • ACL
    • knee
    Consultant Orthopaedic Surgeon (Sports and knee)
    Consultant Orthopaedic Surgeon (Sports and knee)
    • City Sports Clinic & Sports Orthopaedic Specialist at Owner & Founder
    Mr Willis-Owen is a Consultant Orthopaedic Surgeon specialised in knee surgery and the Royal Bournemouth and Christchurch NHS Trust. His unit is one of the busiest in the UK with around 1000 knee replacements per year. Charles benefited from a first class medical education at Oxford University then trained in Oxford and London. He is qualified in orthopaedic surgery, sports medicine and sports psychology and is both a Fellow of the Royal College of Surgeons and a Member of the Faculty of Sports and Exercise Medicine. He has published over 40 international papers and book chapters, and presented at scientific meetings all around the world. He is on the editorial board of one journal and peer reviews for several others. He has had a number of high impact publications and Faculty 1000 papers. He also provides advice to the orthopaedic industry, the British Standards Institute and is developing his own surgical device. Charles is the owner and founder of both “City Sports Clinic” and “Sports Orthopaedic Specialist”.
  • Dr Wylde is a Research Fellow at the Musculoskeletal Research Unit, University of Bristol. She has worked in orthopaedic health services research for 11 years. Her research interests are primarily in the area of outcomes after joint replacement. Particular interests include: outcome measures, chronic post-surgical pain, pain assessment techniques, quantitative sensory testing and interventions to improve outcomes after surgery. She has been co-applicant on two NIHR Programme Grants for Applied Research; one into improving patients’ experiences and outcomes after joint replacement and one into the treatment and management of chronic pain after knee replacement. Dr Wylde is currently Principal Investigator on a NIHR Research for Patient Benefit grant to investigate the effectiveness and cost-effectivness of outpatient physiotherapy after knee replacement.
    • Orthopaedic Surgery
    • Professor and Program Director, Department of Orthopaedic Surgery at UCLA School of Medicine
    Dr. SooHoo is Professor and Program Director for the UCLA School of Medicine, Department of Orthopaedic Surgery. He is a fellow of the American Academy of Orthopaedic Surgeons and has served on the steering committee of the California Joint Replacement Registry as well as the Risk Adjustment Task Force for the American Joint Replacement Registry. His research interests include studying the outcomes and quality of care delivered to patients undergoing total knee replacement.
    • Statistician/PhD, Norwegian Arthroplasty Register at Haukeland University Hospital
    Stein Atle Lie is a statistician/PhD at the Norwegian Arthroplasty register at Haukeland University Hospital in Bergen, Norway. He has been one of the senior statisticians at the Norwegian registry with a more than 20 years record. The Norwegian Arthroplasy Register constitutes today information on almost 200 000 total hip replacements, 70 000 total knee replacements, in addition to data on implants in other joints, cruciate ligaments, hip fractures, and hip diseases in children. Lies research has primarily focused on outcomes for joint implants and mortality after joint replacement surgery. He has a broad record in different fields of medical research and he has published more than 100 scientific articles.
    • Co-director, Orthopedics and Arthritis Center for Outcomes Research at Brigham Health
    Elena Losina, PhD, MSc, is the Co-Director of OrACORe at Brigham and Women's Hospital and Professor of Orthopedics at Harvard Medical School, as well as Adjunct Associate Professor of Biostatistics, Boston University School of Public Health.
    • Rheumatology
    • Emeritus Professor of Rheumatology at The University of Edinburgh
    George Nuki is Emeritus Professor of Rheumatology in the University of Edinburgh He was previously the Arthritis Research Campaign Professor of Rheumatology in the University of Edinburgh and Consultant Rheumatologist at the Western General Hospital and Royal Infirmary of Edinburgh from 1979- 2002. Professor Nuki graduated from King's College and King’s College Hospital Medical School in the University of London in 1960. He completed his postgraduate training in General Internal Medicine and Rheumatology at the Westminster Hospital Medical School in the University of London and the Centre for Rheumatic Diseases at the Royal Infirmary in the University of Glasgow before research training and work as an Attending Physician at the University of California at San Diego. He returned to the UK as Senior Lecturer and subsequently Reader in Rheumatology at the University Hospital of Wales, in Cardiff in 1974. He has undertaken basic and clinical arthritis research for more than 40 years and is the author of research papers, book chapters and reviews in the fields of osteoarthritis and mechanical signal transduction in chondrocytes, as well as osteoporosis, gout and purine metabolism. Professor Nuki was the first President of the British Society for Rheumatology and the Scottish Society for Rheumatology. He is a Master of the American College of Rheumatology and was a member of the External Advisory Board of the UK Medical Research Council, the Board of Trustees of the Arthritis Research Campaign and its Research and Scientific Coordinating Committees. He chaired the ARC Education Committee and was a member of the UK Committee on Safety of Medicines. He was co-chair of the Treatment Guidelines Committee of the Osteoarthritis Research Society International (OARSI) which published evidence-based expert consensus recommendations for the management of osteoarthritis of the hip and knee, a member of the OARSI Board and an Associate Editor of Osteoarthritis and Cartilage.
  • Dr. Oatis’s research program has spanned the range from biomechanical mechanisms of knee joint stiffness in osteoarthritis to examination of factors influencing functional outcomes following total knee replacement. The common thread throughout this program is the focus on improving function in individuals with arthritis. Her current efforts represent a natural progression from basic biomechanical research to outcomes research. Dr. Oatis’s current research, in collaboration with colleagues at the University of Massachusetts Medical School, examines the physical therapy services provided individuals following total knee replacement. Working with a team of orthopedic surgeons, health services researchers, and biostatisticians, Dr. Oatis is investigating characteristics of the physical therapy intervention that are associated with positive functional outcomes. The team utilizes a national database of patients allowing for analyses that help to distinguish between individual patient factors that affect outcomes such as age and obesity and the specific details of the intervention that produce positive outcoms. The goal of this research is to identify “best practices” for physical therapists who treat individuals following total knee replacement.
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