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Dr. Nicole Glaser is a Professor of Pediatrics in the Section of Endocrinology at the University of California, Davis. She holds the Dean’s Endowed Professorship in Pediatric Diabetes Research. Dr. Glaser has conducted extensive research pertaining to pediatric diabetic ketoacidosis and brain injuries caused by DKA in children. Over the past 20 years, she has conducted multiple clinical studies involving children with DKA as well as basic science studies using a juvenile rat model of DKA to explore mechanisms of DKA-related brain injury. Drs. Glaser and Kuppermann have a longstanding history of collaboration in pediatric DKA research. One of their earliest research collaborations explored risk factors for DKA-related brain injuries in children. Data from that study were also published in the New England Journal of Medicine. Dr. Glaser has also been involved in the development of multiple consensus guidelines on the treatment of pediatric DKA on behalf of the International Society for Pediatric and Adolescent Diabetes as well as the Pediatric Endocrine Society and the American Diabetes Association.
Dr. Kuppermann is Professor of Emergency Medicine and Pediatrics, and the Bo Tomas Brofeldt Endowed Chair of the Department of Emergency Medicine at UC Davis. He is a pediatric emergency medicine (PEM) physician and clinical epidemiologist. Research foci include 1) infectious emergencies in children including the laboratory evaluation of young febrile children, 2) the evaluation of children at risk of diabetic ketoacidosis-related cerebral injury, and 3) the laboratory and radiographic evaluation of the pediatric trauma patient. Dr. Kuppermann and his wife Dr. Nicole Glaser have been studying the epidemiology and prevention of DKA-related cerebral injury for nearly two decades, both in children and in a juvenile rat model of DKA. Dr. Kuppermann chaired the first U.S. research network in PEM (the Pediatric Emergency Medicine Collaborative Research Committee of the AAP) from 1996-2000, and led several investigations there. He then became one of the founding investigators and founding Chair of the Steering Committee of the Pediatric Emergency Care Applied Research Network (PECARN) since its inception in 2001 until late in 2008, and remains one of the 7 network PIs. In PECARN, Drs. Kuppermann and Glaser recently completed a ~1400 patient randomized controlled trial of different fluid therapies in pediatric DKA (that is the focus on this discussion!). He also serves on the Executive Committee of the (global) Pediatric Emergency Research Network (PERN), an international consortium of PEM research networks. In 2009, Dr. Kuppermann received the Miller-Sarkin Mentoring Award from the Academic Pediatric Association, and in 2012 received the Jim Seidel Distinguished Service Award, from the Section on Emergency Medicine of the AAP for outstanding contributions to Pediatric Emergency Medicine. In 2010 and 2011, he received national research awards from the EMSC program of HRSA, the Society for Academic Emergency Medicine, and the American College of Emergency Physicians. In 2015, he was recognized with the American College of American Physicians EBSCO/PEMSoft Achievement Award for outstanding contributions to pediatric emergency evidence-based medicine. In 2017 a PEM Scientific Research Mentoring award was named after him by the SAEM. In 2010 he was elected to the National Academy of Medicine.