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Dr. Angus is Chair of the Department of Critical Care Medicine of the University of Pittsburgh School of Medicine and the UPMC Healthcare System. He holds the rank of Distinguished Professor and the Mitchell P. Fink Endowed Chair in Critical Care Medicine with secondary appointments in Medicine, Health Policy and Management, and Clinical and Translational Science and he directs the CRISMA (Clinical Research, Investigation, and Systems Modeling of Acute Illnesses) Center. Dr. Angus’ research interests include clinical, epidemiologic and translational studies of sepsis, pneumonia, and multisystem organ failure and health services research of the organization and delivery of critical care services. Dr. Angus has led several large NIH-funded multicenter studies in the critically ill, published several hundred papers, received numerous awards for his work, and is the critical care editor for JAMA.
Following his PhD in mathematical modelling of disease progression from the University of Cambridge, David joined the Intensive Care National Audit & Research Centre (ICNARC) in 2002. David oversees the statistical work of the Centre, including both its National Audit Programme and the broad programme of research undertaken by the ICNARC Clinical Trials Unit. His main interests are risk prediction modelling, health technology assessment and evaluation of service delivery and organisation in critical care. David was Chief Investigator of the Fungal Infection Risk Evaluation (FIRE) and Risk Adjustment In Neurocritical care (RAIN) research studies. David is a Fellow of the Royal Statistical Society and an Honorary Professor in the Department of Medical Statistics at the London School of Hygiene & Tropical Medicine.
Richard holds a senior research fellowship from the National Institute for Health Research (NIHR), and leads a team undertaking methodological and applied work on health economic evaluation. His main research interests are in improving statistical methods for cost-effectiveness analysis, specifically addressing issues of external validity, non-compliance and confounding. Richard has extensive experience of designing and analysing cost-effectiveness studies based on RCTs and decision models. He has published evaluations across a diverse range of clinical areas including hepatitis C, stroke, elective and emergency surgery, paediatric intensive care and cardiovascular disease, and has a particular interest in critical care medicine. Richard has over 75 publications in peer-reviewed journals, and grants from the research councils and NIHR that total around £15 million. He is an Associate Editor for the US journal Medical Decision Making, and is on the College of experts for NIHR, ESRC and MRC.