Literature
Curbside Consults Podcast
Published June 26, 2020
In this episode of Curbside Consults: Statistical Review, we explore the interpretation of secondary outcomes in clinical trials using the following two articles recently published in NEJM:
Bonaca MP et al. Rivaroxaban in Peripheral Artery Disease after Revascularization
Cao B et al. A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19
To help explain the approach to outbreak study analysis, we are joined once again by Dr. David Harrington, statistical consultant at NEJM and Professor Emeritus of Biostatistics at Harvard T.H. Chan School of Public Health.
0:00 – Introduction
1:54 – Defining primary and secondary outcomes
3:53 – Value of secondary outcomes in trials
4:50 – Principles of interpreting secondary outcomes
6:00 – Interpreting secondary outcomes that are variations of the primary outcome
8:30 – Hierarchical testing and prespecified testing
12:00 – Mortality as a secondary outcome
14:16 – Interpreting safety outcomes
17:12 – p values in secondary outcomes
20:21 – Outro
Resources and articles discussed in this episode:
1. Bonaca MP et al. Rivaroxaban in Peripheral Artery Disease after Revascularization
2. Curbside Consults: Rivaroxaban for Reducing Vascular Event Risks after Limb Revascularization for Peripheral Artery Disease – The VOYAGER PAD Trial with Dr. Marc Bonaca
3. Cao B et al. A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19
4. Curbside Consults: Statistical Review on Power
5. Curbside Consults: Statistical Review on Composite Outcomes
The Curbside Consults series complements the foundational information in Rotation Prep by taking a deep dive into key clinical topics with expert clinicians and educators. These podcasts explore and critique the evidence behind clinical practice and break down statistical concepts for the busy clinical trainee.