To help explain the approach to outbreak study analysis, we are joined once again by Dr. David Harrington, statistical consultant at NEJM and Professor Emeritus of Biostatistics at Harvard T.H. Chan School of Public Health.
0:00 – Introduction 1:54 – Defining primary and secondary outcomes 3:53 – Value of secondary outcomes in trials 4:50 – Principles of interpreting secondary outcomes 6:00 – Interpreting secondary outcomes that are variations of the primary outcome 8:30 – Hierarchical testing and prespecified testing 12:00 – Mortality as a secondary outcome 14:16 – Interpreting safety outcomes 17:12 – p values in secondary outcomes 20:21 – Outro
The Curbside Consults series complements the foundational information in Rotation Prep by taking a deep dive into key clinical topics with expert clinicians and educators. These podcasts explore and critique the evidence behind clinical practice and break down statistical concepts for the busy clinical trainee.
David Harrington is Emeritus Professor of Biostatistics and Statistics at Harvard T.H. Chan School of Public Health
Ken Wu is a 2019-2020 NEJM Editorial Fellow and a paediatrician working in the National Health Service of the United Kingdom. He graduated from Imperial College School of Medicine and is training in general paediatrics in London.