Statistical Review – Power with Dr. David Harrington
Ever read a paper and feel a bit confused about all the statistical jargon and how to properly interpret the findings? At NEJM Resident 360, we’re trying something new and bringing you Statistical Review which aims to cover some key areas in research methodology and trial design. On this episode, Dr Dave Harrington our statistical editor here at the NEJM discusses power and factors that influence power in clinical trials.
00:00 Introduction 01:04 Understanding different outcomes in trials that study similar drugs 02:08 What is power? 03:14 Setting power 05:16 Factors that influence power 07:04 Calculating power 07:59 Can sample size be changed during and after trial 10:28 Interpreting per protocol and intention to treat results 13:16 Summary of power
The Curbside Consults series complements the foundational information in NEJM R360 Rotation Prep by taking a deep dive into key clinical topics with expert clinicians and educators. These podcasts explore and critique the evidence behind clinical practice and break down statistical concepts for the busy clinical trainee.
David Harrington is Emeritus Professor of Biostatistics and Statistics at Harvard T.H. Chan School of Public Health
Amanda Fernandes is a 2018-2019 NEJM editorial fellow.