Statistical Review – Power with Dr. David Harrington


Ever read a paper and feel a bit confused about all the statistical jargon and how to properly interpret the findings? At NEJM Resident 360, we’re trying something new and bringing you Statistical Review which aims to cover some key areas in research methodology and trial design. On this episode, Dr Dave Harrington our statistical editor here at the NEJM discusses power and factors that influence power in clinical trials.

00:00 Introduction
01:04 Understanding different outcomes in trials that study similar drugs
02:08 What is power?
03:14 Setting power
05:16 Factors that influence power
07:04 Calculating power
07:59 Can sample size be changed during and after trial
10:28 Interpreting per protocol and intention to treat results
13:16 Summary of power

Listen to the related podcast on VTE Prophylaxis in Patients with Cancer with Dr. Jean Connors.

The Curbside Consults series complements the foundational information in NEJM R360 Rotation Prep by taking a deep dive into key clinical topics with expert clinicians and educators. These podcasts explore and critique the evidence behind clinical practice and break down statistical concepts for the busy clinical trainee.

 David Harrington is Emeritus Professor of Biostatistics and Statistics at Harvard T.H. Chan School of Public Health

 Amanda Fernandes is a 2018-2019 NEJM editorial fellow.