Statistical Review – Composite Outcomes with Dr. David Harrington


Composite outcomes are frequently used as primary outcomes in randomized-controlled trials and observational studies. Why are they used? What are the limitations of their use? How are composite outcomes interpreted? Join us in this episode as Dr. David Harrington, statistical editor at the NEJM, helps breakdown composite outcomes.


00:00 Introduction
01:20 What is a composite outcome?
01:50 When designing a clinical trial, why do researches use a composite outcome?
04:07 Issues surrounding use of composite outcomes
05:04 How do you interpret composite outcomes
06:06 Understanding the use of composite outcomes in the POET trial
08:27 Summary of the podcast

The Curbside Consults series complements the foundational information in NEJM R360 Rotation Prep by taking a deep dive into key clinical topics with expert clinicians and educators. These podcasts explore and critique the evidence behind clinical practice and break down statistical concepts for the busy clinical trainee.

 David Harrington is Emeritus Professor of Biostatistics and Statistics at Harvard T.H. Chan School of Public Health

 Amanda Fernandes is a 2018-2019 NEJM editorial fellow.

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