Diagnosis and Treatment of C. difficile Infection with Dr. Jessica Allegretti
In this episode of Curbside Consults, we examine the latest guidelines on the management of Clostridiodes difficile (C. difficile) infection. This year, updated guidelines were developed by the Infectious Diseases Society of America and Society for Healthcare Epidemiology of America, as well as the American College of Gastroenterology. Here, we discuss diagnosis and treatment of C. difficile infection through the lens of a clinical case with one of the guideline authors, Dr. Jessica Allegretti, a gastroenterologist at Brigham and Women’s Hospital.
00:05 – Introduction 00:59 – Overview of guideline development 03:35 – What’s new in these updated guidelines 05:29 – Introduction to clinical case 06:07 – Diagnosing C. difficile infection 08:04 – Fidoximicin versus vancomycin for first-line treatment 09:34 – Treatment of recurrent C. difficile infection 10:59 – Bezlotoxumab for prevention of recurrence 12:38 – Risk factors for recurrence 13:35 – C. difficile prophylaxis 17:02 – Fecal microbiota transplantation 20:07 – Final learning points 21:00 – Concluding remarks
The Curbside Consults series complements the foundational information in Rotation Prep by taking a deep dive into key clinical topics with expert clinicians and educators. These podcasts explore and critique the evidence behind clinical practice and break down statistical concepts for the busy clinical trainee.
Dr. Jessica Allegretti is Associate Director of the Crohn's and Colitis Center and a gastroenterologist at Brigham and Women’s Hospital.
Leslie is a 2021-2022 NEJM Editorial Fellow and a hospitalist at Massachusetts General Hospital. She graduated from Duke University School of Medicine in 2018 and completed her internal medicine residency at Massachusetts General Hospital in 2021.