Literature
Curbside Consults Podcast
Published June 13, 2019
Infective endocarditis is a rare infection associated with a high mortality. Patients are often admitted for prolonged periods of time to receive antibiotics. The Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis or the POET trial asked the question whether patients with left sided infective endocarditis can be switched to oral treatment after stabilization on intravenous antibiotics. In this episode, our expert Dr Henry Chambers discusses infective endocarditis and the recently published POET trial.
00:00 Introduction
01:23 Microbiology of infective endocarditis (IE)
04:11 Clinical signs and symptoms of IE
06:10 Diagnosis of IE
08:56 Imaging for IE
11:37 General treatment principles for IE
14:11 Surgical Indications for IE
15:20 Why is the POET trial important?
16:59 Trial design and patient characteristics
22:07 Antibiotic regimen in the trial
23:54 Primary outcome in the trial
25:38 Summary of the podcast
27:00 Conclusion
Additional Resources:
1. Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis
2. Infective Endocarditis
The Curbside Consults series complements the foundational information in NEJM R360 Rotation Prep by taking a deep dive into key clinical topics with expert clinicians and educators. These podcasts explore and critique the evidence behind clinical practice and break down statistical concepts for the busy clinical trainee.
