Geurin C et al. for the PROSEVA Study Group. N Engl J Med 2013.
In the multicenter PROSEVA trial, 466 patients with moderate-to-severe ARDS (P/F ratio <150) were randomized within 36 hours of intubation and mechanical ventilation to the prone or supine position. Prone positioning reduced 28-day (16% vs. 33%, P<0.001) and 90-day mortality (24% vs. 41%, P<0.001). All centers had used prone positioning in daily practice for more than 5 years and complication rates were similar in the two groups.
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