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The Acute Respiratory Distress Syndrome Network (ARDSnet). N Engl J Med 2000.
This landmark RCT showed improved outcomes with lower tidal volumes in patients with ARDS and acute lung injury. It revolutionized ventilator management.
Read the NEJM Journal Watch Summary
The SAFE Study Investigators. N Engl J Med 2004.
An early RCT showing no benefit from albumin, compared to saline, in patients in the ICU.
Pandharipande PP et al. for the BRAIN-ICU Study Investigators. N Engl J Med 2013.
A cohort study examining the long-term cognitive effects of critical illness and delirium.
Mouncey et al. for the ProMISe Trial Investigators. N Engl J Med 2015.
A recent RCT showing that a strict protocol of early-goal directed therapy has no impact on outcomes in patients receiving early fluid resuscitation and antibiotic therapy.
Caironi P et al. for the ALBIOS Study Investigators. N Engl J Med 2014.
A more recent RCT confirming no survival advantage from using albumin over saline in patients with septic shock.
Papazian L et al. for the ACURASYS Study Investigators. N Engl J Med 2010.
An RCT showing improved 90-day survival and increased time off the ventilator with early administration of a neuromuscular blocking agent.
Holst LB et al. for the TRISS rial Group and the Scandinavian Critical Care Trials Group. N Engl J Med 2014.
An RCT showing no difference in 90-day mortality or ischemic events between using a higher or lower hemoglobin threshold in patients with septic shock.
Russell JA et al. for the VASST Investigators. N Engl J Med 2008.
This RCT showed no difference in 28-day mortality between vasopressin and norepinephrine in treating patients with septic shock.