The Acute Respiratory Distress Syndrome Network (ARDSnet). N Engl J Med 2000.
This landmark RCT showed improved outcomes with lower tidal volumes in patients with ARDS and acute lung injury. It revolutionized ventilator management.
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The SAFE Study Investigators. N Engl J Med 2004.
An early RCT showing no benefit from albumin, compared to saline, in patients in the ICU.
Pandharipande PP et al. for the BRAIN-ICU Study Investigators. N Engl J Med 2013.
A cohort study examining the long-term cognitive effects of critical illness and delirium.
Mouncey et al. for the ProMISe Trial Investigators. N Engl J Med 2015.
A recent RCT showing that a strict protocol of early-goal directed therapy has no impact on outcomes in patients receiving early fluid resuscitation and antibiotic therapy.
Caironi P et al. for the ALBIOS Study Investigators. N Engl J Med 2014.
A more recent RCT confirming no survival advantage from using albumin over saline in patients with septic shock.
Papazian L et al. for the ACURASYS Study Investigators. N Engl J Med 2010.
An RCT showing improved 90-day survival and increased time off the ventilator with early administration of a neuromuscular blocking agent.
Holst LB et al. for the TRISS rial Group and the Scandinavian Critical Care Trials Group. N Engl J Med 2014.
An RCT showing no difference in 90-day mortality or ischemic events between using a higher or lower hemoglobin threshold in patients with septic shock.
Russell JA et al. for the VASST Investigators. N Engl J Med 2008.
This RCT showed no difference in 28-day mortality between vasopressin and norepinephrine in treating patients with septic shock.